DESOXYCORTICOSTERONE ACETATE AND WOUND HEALING

Desoxycorticosterone Acetate and Wound Healing

The effect of desoxycorticosterone acetate (DCA) on the granulation tissue of healing and healed linear laparotomy wounds was studied in young adult male guinea pigs maintained on a complete diet and on a known intake of ascorbic acid. DCA induces the production of an excessive amount of granulation tissue, as evidenced by a relatively great number of fibroblasts and by a larger amount of groun...

Desoxycorticosterone Acetate

1. Desoxycorticosterone acetate (DCA) and NaCl, in the dosage employed in normal rats, caused renal and cardiac hypertrophy, characteristic changes in the renal tubular epithelium, atrophic changes in the subcapsular zone of the adrenal cortex, and serum electrolyte changes characterized by a rise in sodium and fall in potassium. 2. In rats rendered nephritic with a rabbit anti-rat-kidney serum...

The effect of desoxycorticosterone acetate on water and electrolyte distribution.

Pressor activity of desoxycorticosterone acetate in normotensive and hypertensive subjects.

Desoxycorticosterone acetate, mammary gland growth, and carcinogenesis in mice.

Whether the carcinogenic action of estrogen is an expression solely of its ability to establish and sustain a mammary gland or whether this hormone has in addition to mammary stimulation an independent carcinogenic property per se has been questioned (5). Desoxycortieosterone acetate has been reported to be as effective as estrogen in stimulating the development of mammary glands in young male ...